ABSTRACT
Objective To observe the clinical therapeutic effects and evaluate the security of Huganjiexian decoction combined with conventional therapy on hepatic cirrhosis.MethodsBy the randomized and prospective study method,34 patients with liver cirrhosis were divided into experimental group and control group.The experimental group was treated with Huganjiexian decoction combined with conventional therapy while the control group was treated with conventional therapy alone.Patients in both groups were treated six months.At the beginning and 6 months after treatment,levels of alanine transaminase (ALT),aspartate transaminase (AST),albumin (ALB),albumin/globulin (A/G),total bilirubin (TBiL),blood urea nitrogen (BUN),serum creatinine (Scr) were determined.Results Levels ofALT、AST、TBiL decreased in both groups after being treated for six months,and the differences of downward trend of the experimental group were more significant than control group (F=36.63,40.31,38.65,P＜0.05).Levels ofALT、AST、TBiL of the experimental group were lower than those of control group significantly (F=8.67,7.62,4.36,P＜0.05 ).The A/G raised in both groups after treatment,and the upward trend of the experimental group was greatly different from that of control group (F=24.10,P＜0.05),the value of A/G of the experimental group was higher than that of control group (F=4.78,P＜0.05).The ALB raised in both groups after treatment,while the upward trend of the experimental group was no different from that of control group (F=0.89,P＞ 0.05).Thevalue of ALB had no significant changes in both groups (F=3.15,P＞0.05).Conclusion Huganjiexian decoction possessed therapeutic effect on hepatic cirrhosis,it had no obvious toxicity and side
ABSTRACT
Objective To observe the blind area in routine gastric lavage and evaluate its significance. Methods Each of 10 healthy volunteers drank 60 ml water containing 185 MBq 99mTc. Images of mouth, esophagus and stomach of all subjects were collected from anterior position with gamma camera, and intraoral and intraesophageal radiocounts were monitored with " Region of Interesting" technique at 0, 0.5, 1,2,3 and 4 hours. Ratios of the counts at subsequent time points vs the count of 0 hour were calculated. For other 13 volunteers, 100 ml, 200 ml, 300 ml and 400 ml normal saline containing 25% compound meglucamine diatrizoate were drunk and injected into stomachs through stomach tube respectively. After that, X-ray chest films were taken at the dorsal and left lateral decubitus positions to observe the oral and e-sophageal developments. Results The images of mouths and esophagus of 10 subjects could be identified more than 4 hours after the administration of 99mTc. The ratios of oral counts and esophageal counts at 0. 5 ,1, 2, 3 and 4 hrs were 30. 7% , 10. 5% , 6. 3% , 4. 7% , 3. 7% , and 18. 6% , 4. 4% , 3. 5% , 3. 0% ,2. 7% respectively. The ratios of both oral and esophageal counts were 49. 3% , 14. 9% , 9. 8% , 7. 7% and 6.4%. When the liquid was drunk, full oral and esophageal developments could be identified. While the liquid was injected through the tube, no development was found. Conclusions Liquid drug may remain in mouth and esophagus for a long period of time after administration. Routine gastric lavage through nasogastric tube can not clean the oral and esophageal drug residues. There are oral and esophageal blind areas when routine gastric lavage is employed.